03 Hypercoagulable States
![](https://photos.thisispiggy.com/file/wikiFiles/iadkmNW.jpg)
Common Hypercoagulable States
![](https://photos.thisispiggy.com/file/wikiFiles/2jKJM78.jpg)
- inflammation: ongoing clot formation
![](https://photos.thisispiggy.com/file/wikiFiles/9cgM7XB.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/1KfXLBe.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/ZFFlt9k.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/9rFrS8z.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/9tudypa.jpg)
Inherited Hypercoagulable States
![](https://photos.thisispiggy.com/file/wikiFiles/es5uEOi.jpg)
- also antiphosphilid syndrome
Factor 5 Leiden
![](https://photos.thisispiggy.com/file/wikiFiles/hI018R0.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/amB5L0u.jpg)
Prothrombin Gene Mutation
![](https://photos.thisispiggy.com/file/wikiFiles/FDD9qY9.jpg)
AIII
![](https://photos.thisispiggy.com/file/wikiFiles/JFBFEAL.jpg)
- given high dose of heparin but no change in PTT
Protein C/S
![](https://photos.thisispiggy.com/file/wikiFiles/8a8UVXW.jpg)
Antiphospholipid
![](https://photos.thisispiggy.com/file/wikiFiles/OxeX2aa.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/5ujkF01.jpg)
- arterial thrombosis uncommon
![](https://photos.thisispiggy.com/file/wikiFiles/zIJNYMJ.jpg)
- 3 anti-phospholipid antibodies
![](https://photos.thisispiggy.com/file/wikiFiles/AQofDWm.jpg)
- RPR antigen bound by syphillis antibodies, but also can be bound by anti-cardiolipin antibodies
![](https://photos.thisispiggy.com/file/wikiFiles/HvxTqJh.jpg)
- intrinsic cascade requires phospholipids. In body on cell membrane. In lab added extrinsically. Lupus anticoagulant will inactivate phospholipids added = false prolongation of PTT
![](https://photos.thisispiggy.com/file/wikiFiles/IktFCAv.jpg)
- contact factor activates 12
![](https://photos.thisispiggy.com/file/wikiFiles/QfVRbWa.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/FhCtlX3.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/zCDGiq5.jpg)
- people have antibodies but not syndrome
![](https://photos.thisispiggy.com/file/wikiFiles/s9oUPkY.jpg)
- clotting factors: blue circles
- lupus anticoagulant: triangles
- mixing study: still prolonged PTT
![](https://photos.thisispiggy.com/file/wikiFiles/MxBqz5B.jpg)
- hemophilia: clotting factor deficiency
![](https://photos.thisispiggy.com/file/wikiFiles/AXsqETs.jpg)
- unprovoked: didn't occur after plane flight/surgery
Backlinks