03 Hypercoagulable States
Common Hypercoagulable States
- inflammation: ongoing clot formation
Inherited Hypercoagulable States
- also antiphosphilid syndrome
Factor 5 Leiden
Prothrombin Gene Mutation
AIII
- given high dose of heparin but no change in PTT
Protein C/S
Antiphospholipid
- arterial thrombosis uncommon
- 3 anti-phospholipid antibodies
- RPR antigen bound by syphillis antibodies, but also can be bound by anti-cardiolipin antibodies
- intrinsic cascade requires phospholipids. In body on cell membrane. In lab added extrinsically. Lupus anticoagulant will inactivate phospholipids added = false prolongation of PTT
- contact factor activates 12
- people have antibodies but not syndrome
- clotting factors: blue circles
- lupus anticoagulant: triangles
- mixing study: still prolonged PTT
- hemophilia: clotting factor deficiency
- unprovoked: didn't occur after plane flight/surgery
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